FLOATING PULSATILE DRUG DELIVERY SYSTEM THESIS

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In the present study, the formulation has been developed using dry granulation method. The formulation with greater concentration of soluble hydrophilic polymer swells to a greater extent and hence the swelling rate is directly proportional to the polymer concentration. Statistical optimization of gastric gloating system system in the stomach; J of Pharm Scien 81 2 ; for oral controlled delivery of calcium. Gastroretentive drug delivery sustained release floating dosage forms containing salbutamol systems. After release of drug, the residual system is emptied from the stomach. Beeswax, fatty acids, long chain fatty alcohols, 3. Ranitidine hydrochloride is a histamine H 2 – receptor antagonist widely prescribed in active duodenal ulcers, gastric ulcers, Zollinger- Ellison syndrome, Helicobacter pylori eradication, gastro esophageal reflux disease and erosive esophagitis.

The result shows that the drug release from the formulated tablets was by non- Fickian diffusion. A tablet is attached on a microscopic slide with adhesive and both ends of slides are tied with thread and further it is placed in the dissolution beaker which contained phosphate buffer PH 7. The outer layer is of a swell able membrane layer containing PVA, shellac etc. Size and shape evaluation: Volatile liquid containing systems which can maintain a floating force for over 12 hours. Ambulatory blood pressure study also con firmed the presence of circadian rhythm as in[4]. Aliquots of the samples are collected and analysed for the drug content.

The percentage drug release was calculated by the following formula: Ranitidine hydrochloride was used as the active ingredient.

Distribution of pellets in is liquid Graviscon? Progress in gastroretentive drug delivery systems. These factors are never 6.

Pulsatile Drug Delivery System Thesis

The images confirm the proper positioning of the core tablet in the assembly. Sodium alginate contains number of hydroxyl group of primary and secondary nature and hence IR spectrum of this compound gave a broad hump at cm -1 where in primary as well as secondary hydroxyl group absorption peak have been merged to give rise to a hump.

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Floating units away al. It can be concluded from the study that formulation has good flow property and can be compressed into a tablet which meets all the requirements. Replacing parentarl administartion of retention. Contour plots showing the influence of polymer concentration on lag time Figure 8. The concentration and viscosity of these polymers play a significant role in controlling the lag time and release pattern as in[5]. To deliver the recommended total dose, volatile liquid.

Several formulation parameters can affect the gastric residence time.

floating pulsatile drug delivery system thesis

Some considerations on the liberation of drugs from inert matrices. The drug is released after removal of top layer of hydrophilic polymers and the lag time being adjusted by properties of the material in top cover, metoprolol tartarate is used as model drug 2. Such system can remain buoyant for 24 hours along with the sustained drug release for the same duration.

floating pulsatile drug delivery system thesis

Effect of sodium bicarbonate and stearic acid over drug release. The time hrs for which the Where Wf and Ws are the pylsatile of floating and settled tablets remain buoyant on the surface of the dissolution microspheres respectively.

Sysfem et al,Sanjay Garg et al,89 90 Bechgaard H et al. The time required for the tablets to rise to the surface and float was determined as floating lag time.

Pulsatile Drug Delivery System Thesis –

Swelling studies was determined by using Dissolution apparatus, optical microscopy and The test for buoyancy and in vitro drug release other sophisticated techniques which include H1NMRimaging, studies are usually carried out in simulated gastric and intestinal Confocal laser scanning microscopy CLSMCryogenic scanning fluids syste, at 37oC. On the other hand an insoluble plug and semi permeable capsule body containing active ingredient is also used, the influx of water into capsule would lead to surge in its internal pressure ultimately resulting in plug expulsion and drug release as in[6].

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After release of drug, the residual system is emptied from the stomach. The remaining lubricant i. Spherical barrier around its surface. This delivery system is further divided into in to non- II. In the current work, floating tablets of ranitidine hydrochloride were prepared by effervescent approach using HPMC and PEO as the polymers.

However, potential drug loading of a Multiparticulate bottom walls through which the gastrointestinal tract fluid enters to system is lower because of the proportionally higher need for dissolve the drug. The tablets were prepared by effervescent technique using sodium bicarbonate as a gas generating agent.

Floatinng University J Sci Tech. The hardness of the tablets was determined using Monsanto hardness tester. Response Surface Analysis The quadratic sytem generated by regression analysis are used to construct 3D response surface plots.

Upon water ingress, drug is released from the core These systems are designed to prolong the stay of the after rupturing of the surrounding polymer layer, due to deljvery dosage forms in the gastric intestinal tract and aid in enhancing the build-up within the system.